CLOVES Syndrome

CLOVES Syndrome


CLOVES syndrome is an extremely rare overgrowth syndrome with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs.


CLOVES syndrome is a rare condition that is primarily characterized by congenital overgrowth of fatty tissue, malformations of the vascular system, and spinal or skeletal abnormalities. Other signs and symptoms may include disproportionate fat distribution, overgrowth of the arms and legs, skin abnormalities and kidney problems such as an unusually small or absent kidney.


CLOVES syndrome is caused by somatic mutations in the PIK3CA gene.


Less than 1:1’000’000

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Last Updated on 17 May 2021