Drummond’s Syndrome (Blue Diaper Syndrome)

Drummond’s Syndrome (Blue Diaper Syndrome)


Blue diaper syndrome is a rare, autosomal recessive metabolic disorder characterized in infants by bluish urine-stained diapers.


Symptoms typically include digestive disturbances, fever and visual problems.


Blue diaper Syndrome is caused by a defect in tryptophan absorption. Bacterial degradation of unabsorbed tryptophan in the intestine leads to excessive indole production and thus to indicanuria which, on oxidation to indigo blue, causes a peculiar bluish discoloration of the diaper (indoluria).



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Last Updated on 17 May 2021