Fibrodysplasia Ossificans Progressiva

Fibrodysplasia Ossificans Progressiva


Fibrodysplasia ossificans progressiva (FOP) is a disorder in which skeletal muscle and connective tissue, such as tendons and ligaments, are gradually replaced by bone (ossified). This condition leads to bone formation outside the skeleton.


The mutation affects the body’s repair mechanism, causing fibrous tissue including muscle, tendons, and ligaments to be ossified, either spontaneously or when damaged as the result of trauma. In many cases, otherwise minor injuries can cause joints to become permanently fused as new bone forms and replaces the damaged muscle tissue. This new bone formation (known as “heterotopic ossification”) eventually forms a secondary skeleton and progressively restricts the patient’s ability to move. Bone formed as a result of this process is identical to “normal” bone, simply in improper locations.


Fibrodysplasia ossificans progressiva is caused by a mutation of the gene ACVR1.


Probably 1:2’000’000


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Last Updated on 17 May 2021